1:47 AM
kotesh
Every living cells contains DNA, RNA and proteins. closely related organisms generally have degree of agreement in the molecular structure of these substances, Heterogeneous nuclear ribonucleic proteins are spliceosomal macromolecular assemblages and thus actively participate in pre - mRNA metabolism.
Conserved sequences, such as mitochondrial DNA are expected to accumulate mutations over time and assuming a constant rate of mutation provide molecular interaction features.
Molecular characterization of human hnRNP A3 showed that while the recombinant hnRNP A3 with its 296 amino acids migrates as excepted as 32 kDA protein on SDS-PAGE analysis, it is recognized by the patient's sear as a 50 kda highly related ye unknown cross reactive protein.
The sequence comparision. however may be insufficient for deduction of its functional role patients diagnozed with the suspected disease. therefore we followed the suggestion of pointing CS and Russel RRSurprisingly, neither the 50 kda nor the 32kda protein was detected in the suspected disease.
Conserved sequences, such as mitochondrial DNA are expected to accumulate mutations over time and assuming a constant rate of mutation provide molecular interaction features.
Molecular characterization of human hnRNP A3 showed that while the recombinant hnRNP A3 with its 296 amino acids migrates as excepted as 32 kDA protein on SDS-PAGE analysis, it is recognized by the patient's sear as a 50 kda highly related ye unknown cross reactive protein.
The sequence comparision. however may be insufficient for deduction of its functional role patients diagnozed with the suspected disease. therefore we followed the suggestion of pointing CS and Russel RRSurprisingly, neither the 50 kda nor the 32kda protein was detected in the suspected disease.
